The 2588G→C Mutation in the ABCR Gene Is a Mild Frequent Founder Mutation in the Western European Population and Allows the Classification of ABCR Mutations in Patients with Stargardt Disease
Identifieur interne : 003893 ( Main/Exploration ); précédent : 003892; suivant : 003894The 2588G→C Mutation in the ABCR Gene Is a Mild Frequent Founder Mutation in the Western European Population and Allows the Classification of ABCR Mutations in Patients with Stargardt Disease
Auteurs : Alessandra Maugeri [Pays-Bas] ; Marc A. Van Driel [Pays-Bas] ; Dorien J. R. Van De Pol [Pays-Bas] ; B. Jeroen Klevering [Pays-Bas] ; Frank J. J. Van Haren [Pays-Bas] ; Nel Tijmes [Pays-Bas] ; Arthur A. B. Bergen [Pays-Bas] ; Klaus Rohrschneider ; Anita Blankenagel ; Alfred J. L. G. Pinckers [Pays-Bas] ; Niklas Dahl [Suède] ; Han G. Brunner [Pays-Bas] ; August F. Deutman [Pays-Bas] ; Carel B. Hoyng [Pays-Bas] ; Frans P. M. Cremers [Pays-Bas]Source :
- The American Journal of Human Genetics [ 0002-9297 ] ; 1999.
English descriptors
- KwdEn :
- Teeft :
- Abc1 subfamily, Abcr, Abcr gene, Abcr mutation, Abcr mutations, Abcr protein, Allele, Allikmets, Amino, Autosomal, Carrier frequencies, Carrier frequency, Cdna, Compound heterozygosity, Control individuals, Control population, Cremers, Cytosine, Deletion, European abcr mutation, Exact test, Exon, Founder mutation, General population, Genet, Genomic, Gerber, Heterozygosity, Heterozygote, Heterozygote frequency, High carrier frequency, Hoyng, Linkage disequilibrium, Macular, Maugeri, Mild abcr mutations, Mild mutation, Mild mutations, Missense, Moderate mutation, Mutant, Mutant cytosine, Mutation, Null mutations, Phenotype, Polymorphism, Primer, Recessive, Rozet, Severe mutation, Severe mutations, Splice, Splice site, Stargardt, Stargardt disease, Stgd, Stgd patient, Stgd patients, Transporter.
Abstract
SummaryIn 40 western European patients with Stargardt disease (STGD), we found 19 novel mutations in the retina-specific ATP-binding cassette transporter (ABCR) gene, illustrating STGD's high allelic heterogeneity. One mutation, 2588G→C, identified in 15 (37.5%) patients, shows linkage disequilibrium with a rare polymorphism (2828G→A) in exon 19, suggesting a founder effect. The guanine at position 2588 is part of the 3′ splice site of exon 17. Analysis of the lymphoblastoid cell mRNA of two STGD patients with the 2588G→C mutation shows that the resulting mutant ABCR proteins either lack Gly863 or contain the missense mutation Gly863Ala. We hypothesize that the 2588G→C alteration is a mild mutation that causes STGD only in combination with a severe ABCR mutation. This is supported in that the accompanying ABCR mutations in at least five of eight STGD patients are null (severe) and that a combination of two mild mutations has not been observed among 68 STGD patients. The 2588G→C mutation is present in 1 of every 35 western Europeans, a rate higher than that of the most frequent severe autosomal recessive mutation, the cystic fibrosis conductance regulator gene mutation ΔPhe508. Given an STGD incidence of 1/10,000, homozygosity for the 2588G→C mutation or compound heterozygosity for this and other mild ABCR mutations probably does not result in an STGD phenotype.
Url:
DOI: 10.1086/302323
Affiliations:
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Van Driel</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Van De Pol, Dorien J R" sort="Van De Pol, Dorien J R" uniqKey="Van De Pol D" first="Dorien J. R." last="Van De Pol">Dorien J. R. Van De Pol</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Klevering, B Jeroen" sort="Klevering, B Jeroen" uniqKey="Klevering B" first="B. Jeroen" last="Klevering">B. Jeroen Klevering</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Van Haren, Frank J J" sort="Van Haren, Frank J J" uniqKey="Van Haren F" first="Frank J. J." last="Van Haren">Frank J. J. Van Haren</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Tijmes, Nel" sort="Tijmes, Nel" uniqKey="Tijmes N" first="Nel" last="Tijmes">Nel Tijmes</name><affiliation wicri:level="3"><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><wicri:orgArea>The Netherlands Ophthalmic Research Institute</wicri:orgArea></affiliation></author><author><name sortKey="Bergen, Arthur A B" sort="Bergen, Arthur A B" uniqKey="Bergen A" first="Arthur A. B." last="Bergen">Arthur A. B. Bergen</name><affiliation wicri:level="3"><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><wicri:orgArea>The Netherlands Ophthalmic Research Institute</wicri:orgArea></affiliation></author><author><name sortKey="Rohrschneider, Klaus" sort="Rohrschneider, Klaus" uniqKey="Rohrschneider K" first="Klaus" last="Rohrschneider">Klaus Rohrschneider</name><affiliation><wicri:noCountry code="subField">Heidelberg</wicri:noCountry></affiliation></author><author><name sortKey="Blankenagel, Anita" sort="Blankenagel, Anita" uniqKey="Blankenagel A" first="Anita" last="Blankenagel">Anita Blankenagel</name><affiliation><wicri:noCountry code="subField">Heidelberg</wicri:noCountry></affiliation></author><author><name sortKey="Pinckers, Alfred J L G" sort="Pinckers, Alfred J L G" uniqKey="Pinckers A" first="Alfred J. L. G." last="Pinckers">Alfred J. L. G. Pinckers</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Dahl, Niklas" sort="Dahl, Niklas" uniqKey="Dahl N" first="Niklas" last="Dahl">Niklas Dahl</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Unit of Clinical Genetics, Department of Genetics and Pathology, Uppsala University Children`s Hospital, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Brunner, Han G" sort="Brunner, Han G" uniqKey="Brunner H" first="Han G." last="Brunner">Han G. Brunner</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Deutman, August F" sort="Deutman, August F" uniqKey="Deutman A" first="August F." last="Deutman">August F. Deutman</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Hoyng, Carel B" sort="Hoyng, Carel B" uniqKey="Hoyng C" first="Carel B." last="Hoyng">Carel B. Hoyng</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Cremers, Frans P M" sort="Cremers, Frans P M" uniqKey="Cremers F" first="Frans P. M." last="Cremers">Frans P. M. Cremers</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Human Genetics</title><title level="j" type="abbrev">AJHG</title><idno type="ISSN">0002-9297</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">64</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1024">1024</biblScope><biblScope unit="page" to="1035">1035</biblScope></imprint><idno type="ISSN">0002-9297</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ABCR</term><term>Founder mutation</term><term>Genotype-phenotype correlation</term><term>Retina</term><term>Retinal dystrophies</term><term>STGD</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abc1 subfamily</term><term>Abcr</term><term>Abcr gene</term><term>Abcr mutation</term><term>Abcr mutations</term><term>Abcr protein</term><term>Allele</term><term>Allikmets</term><term>Amino</term><term>Autosomal</term><term>Carrier frequencies</term><term>Carrier frequency</term><term>Cdna</term><term>Compound heterozygosity</term><term>Control individuals</term><term>Control population</term><term>Cremers</term><term>Cytosine</term><term>Deletion</term><term>European abcr mutation</term><term>Exact test</term><term>Exon</term><term>Founder mutation</term><term>General population</term><term>Genet</term><term>Genomic</term><term>Gerber</term><term>Heterozygosity</term><term>Heterozygote</term><term>Heterozygote frequency</term><term>High carrier frequency</term><term>Hoyng</term><term>Linkage disequilibrium</term><term>Macular</term><term>Maugeri</term><term>Mild abcr mutations</term><term>Mild mutation</term><term>Mild mutations</term><term>Missense</term><term>Moderate mutation</term><term>Mutant</term><term>Mutant cytosine</term><term>Mutation</term><term>Null mutations</term><term>Phenotype</term><term>Polymorphism</term><term>Primer</term><term>Recessive</term><term>Rozet</term><term>Severe mutation</term><term>Severe mutations</term><term>Splice</term><term>Splice site</term><term>Stargardt</term><term>Stargardt disease</term><term>Stgd</term><term>Stgd patient</term><term>Stgd patients</term><term>Transporter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">SummaryIn 40 western European patients with Stargardt disease (STGD), we found 19 novel mutations in the retina-specific ATP-binding cassette transporter (ABCR) gene, illustrating STGD's high allelic heterogeneity. One mutation, 2588G→C, identified in 15 (37.5%) patients, shows linkage disequilibrium with a rare polymorphism (2828G→A) in exon 19, suggesting a founder effect. The guanine at position 2588 is part of the 3′ splice site of exon 17. Analysis of the lymphoblastoid cell mRNA of two STGD patients with the 2588G→C mutation shows that the resulting mutant ABCR proteins either lack Gly863 or contain the missense mutation Gly863Ala. We hypothesize that the 2588G→C alteration is a mild mutation that causes STGD only in combination with a severe ABCR mutation. This is supported in that the accompanying ABCR mutations in at least five of eight STGD patients are null (severe) and that a combination of two mild mutations has not been observed among 68 STGD patients. The 2588G→C mutation is present in 1 of every 35 western Europeans, a rate higher than that of the most frequent severe autosomal recessive mutation, the cystic fibrosis conductance regulator gene mutation ΔPhe508. Given an STGD incidence of 1/10,000, homozygosity for the 2588G→C mutation or compound heterozygosity for this and other mild ABCR mutations probably does not result in an STGD phenotype.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Suède</li></country><region><li>Gueldre</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Nimègue</li></settlement></list><tree><noCountry><name sortKey="Blankenagel, Anita" sort="Blankenagel, Anita" uniqKey="Blankenagel A" first="Anita" last="Blankenagel">Anita Blankenagel</name><name sortKey="Rohrschneider, Klaus" sort="Rohrschneider, Klaus" uniqKey="Rohrschneider K" first="Klaus" last="Rohrschneider">Klaus Rohrschneider</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Maugeri, Alessandra" sort="Maugeri, Alessandra" uniqKey="Maugeri A" first="Alessandra" last="Maugeri">Alessandra Maugeri</name></noRegion><name sortKey="Bergen, Arthur A B" sort="Bergen, Arthur A B" uniqKey="Bergen A" first="Arthur A. B." last="Bergen">Arthur A. B. Bergen</name><name sortKey="Brunner, Han G" sort="Brunner, Han G" uniqKey="Brunner H" first="Han G." last="Brunner">Han G. Brunner</name><name sortKey="Cremers, Frans P M" sort="Cremers, Frans P M" uniqKey="Cremers F" first="Frans P. M." last="Cremers">Frans P. M. Cremers</name><name sortKey="Deutman, August F" sort="Deutman, August F" uniqKey="Deutman A" first="August F." last="Deutman">August F. Deutman</name><name sortKey="Hoyng, Carel B" sort="Hoyng, Carel B" uniqKey="Hoyng C" first="Carel B." last="Hoyng">Carel B. Hoyng</name><name sortKey="Klevering, B Jeroen" sort="Klevering, B Jeroen" uniqKey="Klevering B" first="B. Jeroen" last="Klevering">B. Jeroen Klevering</name><name sortKey="Maugeri, Alessandra" sort="Maugeri, Alessandra" uniqKey="Maugeri A" first="Alessandra" last="Maugeri">Alessandra Maugeri</name><name sortKey="Pinckers, Alfred J L G" sort="Pinckers, Alfred J L G" uniqKey="Pinckers A" first="Alfred J. L. G." last="Pinckers">Alfred J. L. G. Pinckers</name><name sortKey="Tijmes, Nel" sort="Tijmes, Nel" uniqKey="Tijmes N" first="Nel" last="Tijmes">Nel Tijmes</name><name sortKey="Van De Pol, Dorien J R" sort="Van De Pol, Dorien J R" uniqKey="Van De Pol D" first="Dorien J. R." last="Van De Pol">Dorien J. R. Van De Pol</name><name sortKey="Van Driel, Marc A" sort="Van Driel, Marc A" uniqKey="Van Driel M" first="Marc A." last="Van Driel">Marc A. Van Driel</name><name sortKey="Van Haren, Frank J J" sort="Van Haren, Frank J J" uniqKey="Van Haren F" first="Frank J. J." last="Van Haren">Frank J. J. Van Haren</name></country><country name="Suède"><noRegion><name sortKey="Dahl, Niklas" sort="Dahl, Niklas" uniqKey="Dahl N" first="Niklas" last="Dahl">Niklas Dahl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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